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微小RNA(microRNA,miRNA)是一类广泛存在于动植物中,大小约22 nt的单链非编码小分子RNA.它通过与靶mRNA 3’末端非翻译区(untranslational region,UTR)结合,使mRNA降解或翻译抑制.大量的研究结果表明,miRNA在动植物的生长发育、细胞分化、细胞增殖与凋亡、肿瘤发生等诸多环节发挥着重要的调节作用.目前,miRNA靶基因的筛选方法主要有生物信息学筛选和实验方法两大类,且在互联网上拥有大量相关的网络共享资源.本文通过对现有miRNA靶基因的筛选方法及其相关网络资源进行整理与比较分析,以有效指导并辅助miRNA领域的研究.
MicroRNAs (miRNAs) are a class of single-stranded non-coding small RNAs that are widely found in plants and animals and have a size of about 22 nt. By binding to the 3 ’untranslated region (UTR) of the target mRNA, mRNA degradation or translation inhibition.Many studies have shown that miRNA plays an important regulatory role in many aspects of animal and plant growth and development, cell differentiation, cell proliferation and apoptosis, tumorigenesis, etc. At present, miRNA target gene screening methods mainly There are two kinds of bioinformatics screening and experimental methods, and have a large number of related network sharing resources on the Internet.Through the sorting and comparative analysis of the existing screening methods of miRNA target genes and their related network resources, in order to effectively guide and Assisted miRNA research.