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目的探讨老年女性高血压患者血尿酸水平与超敏CRP浓度和颈动脉血管壁内膜中层厚度(IMT)之间的相关性。方法测定89例老年女性高血压患者血尿酸、超敏CRP(hs-CRP)、空腹血糖(FPG)、甘油三酯(TG)、胆固醇(TC)水平及颈总动脉血管壁内膜中层厚度IMT,按颈总动脉IMT分成内膜正常组、内膜增厚组、斑块形成组、管腔狭窄组,比较各组间血尿酸、超敏CRP(hs-CRP)水平。采用多元回归分析统计血尿酸水平与超敏CRP(hs-CRP)浓度和颈动脉IMT之间的关系。结果血尿酸、hs-CRP与老年女性高血压患者颈动脉IMT增厚有关。结论老年女性高血压患者测定颈动脉IMT、hs-CRP浓度、血尿酸水平,可协助诊断冠心病。
Objective To investigate the relationship between serum uric acid level and CRP concentration in carotid artery intima-media thickness (IMT) in elderly women with hypertension. Methods Serum uric acid, fasting blood glucose (FPG), triglyceride (TG), cholesterol (TC) and carotid artery intima-media thickness were measured in 89 elderly women with hypertension. IMT According to the common carotid artery IMT, the rats were divided into normal intima group, thickening group in intima, plaque formation group and stenosis group. The levels of serum uric acid and hs-CRP in each group were compared. The relationship between serum uric acid level and the concentration of hs-CRP and carotid IMT was analyzed by multivariate regression analysis. Results Serum uric acid and hs-CRP were associated with thickening of carotid IMT in elderly female patients with hypertension. Conclusions Measurement of carotid IMT, hs-CRP concentration and serum uric acid level in elderly women with hypertension can help diagnose coronary heart disease.