中耳胆脂瘤是耳科常见疾病,其发病机理复杂,至今尚未完全明确。国内外学者对其研究主要集中在胆脂瘤上皮细胞的过度增殖性、对骨质的破坏吸收及胆脂瘤上皮细胞凋亡状态等三个方面。本文复习近年来相关文献,重点就其与细胞凋亡关系的研究进展进行综述。 Middle ear cholesteatoma is a common disease of the otology, its pathogenesis is complex, so far not yet completely clear. Domestic and foreign scholars mainly focus on three aspects: the hyperproliferation of cholesteatoma epithelial cells, the destruction and absorption of bone and the apoptosis of cholesteatoma epithelial cells. This review of the literature in recent years, focusing on its relationship with apoptosis in the progress of research are reviewed.