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必需的微量元素铜、锌对细胞免疫的影响，国外近年来的研究较为活跃。研究证实：适宜的铜锌浓度对人及动物Ｔ细胞的分化、增殖是必需的；铜锌不足将削弱机体的细胞免疫功能。本文综述了国外关于此方面研究的一些情况及其进展，包括铜锌不足时动物体内ＣＤ４，ＣＤ８比例失调及对植物血凝素（ＰＨＡ）反应的降低；通过补充铜锌可以提高铜锌不足动物的细胞免疫功能。
The necessary trace elements copper, zinc on cellular immunity, foreign research in recent years more active. Studies have shown that: appropriate concentrations of copper and zinc on human and animal T cells differentiation and proliferation is necessary; lack of copper and zinc will weaken the body’s cellular immune function. This review summarizes some foreign research progress in this area and its progress, including the imbalance of CD4 and CD8 in animals when copper and zinc are deficient and the decrease of phytohaemagglutinin (PHA) response; supplementation of copper and zinc can increase the deficiencies of copper-zinc deficient animals Cellular immune function.