妊娠急性脂肪肝(AFLP)系发生于妊娠后期的一种疾病。临床有呕吐、腹痛、黄疸、出血及肝、肾功能衰竭等。本病进展迅速,病死率高。过去由于对本病的认识不够,而常有误诊或漏诊。为了提高认识,总结经验,特将本病有关文献综述如下。发病概况 1940年Sheehan在400例孕妇尸检中发现本病6例,称为产科急性黄色肝萎缩。其后Ober与LeCompte报告3例,并命名为妊娠期急性肝脂肪变性。1956年Moore始称其为妊娠急性脂肪肝。既往认为AFLP系罕见疾病,其发病率约为孕妇的1/1,000,000。但自1934年首例报 Acute fatty liver of pregnancy (AFLP) is a disease that occurs in late pregnancy. Clinical vomiting, abdominal pain, jaundice, bleeding and liver and kidney failure. The rapid progress of the disease, high mortality. In the past due to lack of understanding of the disease, and often misdiagnosed or missed diagnosis. In order to raise awareness, sum up experience, especially the relevant literature review of the disease are as follows. Morbidity profile Sheehan in 1940 in 400 cases of pregnant women autopsy found in 6 cases of the disease, known as obstetric acute yellow liver atrophy. Then Ober and LeCompte reported 3 cases and named acute hepatic steatosis during pregnancy. Moore in 1956 called it an acute fatty liver of pregnancy. In the past, AFLP was considered a rare disease with a prevalence of about 1 in 1,000,000 of pregnant women. But since the first case in 1934