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目的了解目标人群腹泻病的发病率、痢疾发病率及流行病学特征,建立痢疾流行病学监测体系,为兰州生物制品研究所开展“福氏2 a痢疾结合菌苗及宋内氏痢疾结合疫苗”Ⅲ期临床研究建立基线资料。方法选择长葛市官亭乡舒庄、冢杨和奎府3个自然村为监测点,通过整群抽样方法,在“逢泻必检”的原则上,采用主动监测与被动监测相结合的方式,建立痢疾主动监测模式,采集遴选的3 094名自然人群腹泻病人粪便,检测痢疾病原菌。结果监测点5~10月腹泻发病率为24 952/10万;痢疾发病率为1 293/10万;分离痢疾病原菌均为宋内志贺菌;腹泻发病高峰为8月(188人/3 094),9月痢疾检出率最高(11.11%);较2009年国家大疫情网细菌性痢疾发病报告数据高约出90倍。结论痢疾主动监测模式建立运行良好,监测数据可参考性强。
Objective To understand the incidence of diarrheal diseases, the incidence of diarrhea and epidemiological characteristics of the target population and to establish a epidemiological surveillance system for diarrhea, to carry out the “2” combination of bacillary dysentery and Salivary dysentery in Lanzhou Institute of Biological Products Vaccine "Phase III clinical study to establish baseline data. Methods The three natural villages of Shuzhuang, Tzu-Yang and Kui-fu of Guanting Township in Changge City were selected as monitoring points. Through the method of cluster sampling, the principle of combining active monitoring with passive monitoring was adopted in principle , Set up an active monitoring model for dysentery, collected fecal samples of 3 094 selected diarrhea patients from natural populations and detected dysentery pathogens. Results The incidence of diarrhea was 24 952/10 million in monitoring sites from May to October. The incidence of diarrhea was 13 293/10 million. The pathogenic bacteria isolated from dysentery were Shigella sonnei. The peak incidence of diarrhea was August (188 persons / 3 094 ), The highest detection rate of dysentery was in September (11.11%); it was 90 times higher than that reported in the 2009 national outbreak of bacterial dysentery. Conclusion The active monitoring mode of dysentery is well established and the monitoring data can be referenced strongly.