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藻酸双酯钠为新型类肝素样生理活性药物,用于缺血性心、脑血管病的预防及治疗。我院1988年10月~1989年1月出现静脉滴注该药引起严重低血压和血管神经性水肿8例(其中低血压休克3例,血管神经性水肿5例),特摘要报告如下以供临床应用时注意。例1,女,48岁。诊断:脑动脉硬化,脑血管痉挛。无药物过敏史。入院后口服脑益嗪,静点藻酸双酯钠100mg 加入5%糖500ml 中,1日1次,滴注速度4.5ml/分,第1日滴完后自觉口唇麻木,咽部发堵,未经治疗自行缓解。次日同样滴速点完后5分钟自觉胸闷、气短、咽部阻塞继之呼吸困
Sodium alginate sodium is a new class of heparin-like physiologically active drugs for the prevention and treatment of ischemic heart and cerebrovascular diseases. Our hospital from October 1988 to January 1989 appeared intravenous infusion of this medicine caused by severe hypotension and angioneurotic edema in 8 cases (including 3 cases of hypotension shock, 5 cases of angioedema), special summary report as follows for Note the clinical application. Example 1, female, 48 years old. Diagnosis: cerebral arteriosclerosis, cerebral vasospasm. No history of drug allergy. After admission, oral brain Yizhizhin, sodium alginate 100mg intravenous injection of 5% sugar 500ml, 1 on the 1st, the infusion rate of 4.5ml / min, the first day after the end of conscious lip numbness, pharyngeal hair blocking, Without treatment to ease. The same day after the same drip point 5 minutes after conscious chest tightness, shortness of breath, pharyngeal obstruction followed by breathing difficulties