Apolipoprotein (a) [Lp(a)] phenotypes of 69 myocardial infarction survivor and 56 stroke patients were reported and compared to those of 190 healthy Chinese. The results revealed that the distributions of apo(a) phenotype frequency in patients with cardio-cerebrovascular disease (CCVD) were different from those of controls. The frequency of the phenotypes S_1, and S_2 were remarkably higher in patients than in controls within the same single-band apo(a) phenotype. Moreover, the Lp (a) serum concentrations in CCVD patients were significantly higher than in controls within the same single-band apo (a) phenotype. The apo (a) phenotype analysis of two pedigrees were shown as a typical autosmal dominant inheritance. The results revealed that the distributions of apo (a) phenotype frequency in patients with cardio-cerebrovascular The frequency of the phenotypes S_1, and S_2 were remarkably higher in patients than in controls within the same single-band apo (a) phenotype. Moreover, the Lp (a) serum concentrations in The apo (a) phenotype analysis of two pedigrees were shown as a typical autosmal dominant inheritance.