论文部分内容阅读
目的探讨淋巴管内皮细胞透明质酸受体-1(LYVE-l)在肝癌组织中的表达及其临床意义。方法采用蛋白质印迹法检测24例低分化肝细胞癌,6例高分化肝细胞癌和30例正常肝组织中LYVE-1的蛋白表达。结果肝癌组织LYVE-l表达阳性。低分化肝癌组织中LYVE-l的表达高于高分化肝癌组织二者均显著高于正常肝组织(P<0.05)。结论 LYVE-1可作为肝癌组织的淋巴管特异性标志物,为肝癌的预后提供了一种更有效的研究手段。
Objective To investigate the expression of hyaluronic acid receptor-1 (LYVE-1) in lymphatic endothelial cells and its clinical significance. Methods The protein expression of LYVE-1 in 24 cases of poorly differentiated hepatocellular carcinoma, 6 cases of well-differentiated hepatocellular carcinoma and 30 cases of normal liver tissue was detected by Western blotting. Results The positive expression of LYVE-1 in HCC tissues. The expression of LYVE-1 in poorly differentiated HCC tissues was significantly higher than that in well-differentiated HCC tissues (P <0.05). Conclusion LYVE-1 can be used as a lymphatic-specific marker of liver cancer, which provides a more effective means for the prognosis of liver cancer.