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目的:探讨妊娠合并地中海贫血与弓形体(TOX)感染之间的相关性。方法:收集1 247例孕妇血液,采用红细胞脆性试验“一管法”进行地中海贫血的初步筛查并对可疑贫血及地中海贫血病例再进行基因分型;利用聚合酶链反应法检测TOX DNA阳性率,同时用五分类血球计数仪测定血红蛋白(Hb)和平均红细胞体积(MCV)并进行比较。结果:1 247例孕妇中地中海贫血118例,阳性率为9.46%;TOX感染159例,阳性率为12.75%;地中海贫血与TOX合并感染者96例,阳性率为7.70%,地中海贫血合并TOX感染之间存在显著性相关。在进一步对Hb、平均红细胞体积(MCV),谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转肽酶(GGT)检测中发现孕妇地中海贫血合并TOX感染组分别与单纯地中海贫血或单纯TOX感染组比较,两组之间差异有统计学意义(P<0.05)。结论:妊娠合并地中海贫血的血液中存在着TOX合并感染,且可能与地中海贫血的发展密切相关。
Objective: To investigate the correlation between pregnancy-associated thalassemia and toxoplasma (TOX) infection. Methods: A total of 1 247 pregnant women were collected for blood transfusion. The primary screening of thalassemia was conducted using the red blood cell fragility test “One tube method” and genotyping of suspected anemia and thalassemia. The TOX DNA was detected by polymerase chain reaction Positive rate, while hemoglobin (Hb) and mean corpuscular volume (MCV) were measured and compared using a five-category haemocytometer. Results: A total of 118 cases of thalassemia were found in 1 247 pregnant women, the positive rate was 9.46%. In TOX infection, 159 cases were positive, with a positive rate of 12.75%. 96 cases were found to be associated with TOX. The positive rate was 7.70%. Thalassemia was associated with TOX infection There is a significant correlation between. The levels of Hb, MCV, ALT, AST and GGT in pregnant women were also significantly lower than those in thalassemia or thalidomide alone The difference between the two groups was statistically significant (P <0.05). Conclusion: There is a TOX co-infection in the blood of pregnant women with thalassemia and may be closely related to the development of thalassemia.