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目的:观察~(153)Sm—EDTMP[~(153)钐乙二胺四亚甲基膦酸(EDTMP)]治疗恶性肿瘤骨转移的疼痛和活动障碍的疗效。方法:43例恶性肿瘤骨转移病人(男性32例,女性11例),年龄58.21±11.63岁,应用~(153)Sm—EDTMP治疗2～5次。结果:止痛有效率79.07％。合并化疗、放疗或以骨膦为主的生物治疗者较单用~(153)Sm—EDTMP者疗效好。对活动障碍的有效率为51.16％。结论:应用~(153)Sm—EDTMP治疗恶性肿瘤骨转移病人,能有效减轻病人疼痛,改善活动障碍。
OBJECTIVE: To observe the efficacy of ~(153)Sm-EDTMP[~(153)钐-ethylenediaminetetramethylenephosphonic acid (EDTMP)] in the treatment of pain and movement disorders of bone metastases in malignant tumors. METHODS: Forty-three patients with malignant bone metastases (male 32, female 11) aged 58.21±11.63 years were treated with ~(153)Sm-EDTMP for 2~5 times. Result: The pain relief rate was 79.07%. Compared with single therapy with ~(153)Sm-EDTMP, chemotherapy with biochemotherapy, radiotherapy, or bone-phosphine-based biotherapeutics was effective. The effective rate for activities is 51.16%. Conclusion: The application of ~(153)Sm-EDTMP in the treatment of patients with malignant bone metastasis can effectively relieve pain and improve mobility.