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近年研究发现各种原发性肾脏疾病引起的肾排泄功能的损害与肾小管间质病变的程度密切相关。小管间质的病变为炎症细胞的浸润、小管萎缩和间质纤维化。肾纤维化的特点为结缔组织不适当地积聚，包括间质Ⅰ型胶原、Ⅲ型胶原和Ⅳ型胶原、纤维连接蛋白、各种蛋白聚糖（Ｐｒｏｔ...
Recent studies found that various primary renal disease caused by renal excretion dysfunction and tubulointerstitial lesions are closely related to the degree. Tubulointerstitial lesions are inflammatory cell infiltration, tubule atrophy and interstitial fibrosis. Renal fibrosis is characterized by inappropriate accumulation of connective tissue, including interstitial collagen type I, type III collagen and type IV collagen, fibronectin, various proteoglycans (Prot ...