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恶性疟原虫的抗药性问题日益严重,有研究表明疟原虫对氯喹和甲氟喹的抗性与Pfmdrl基因及其编码产物P-糖蛋白(pgn1)有关,但也有不少不同的实验结果。本文通过对分离自泰国的恶性疟原虫的研究表明,Pfmdrl基因的扩增与甲氟喹的抗性之间没有绝对的关联;核酸序列分析也未能证实在此基因的一些可能引起药物抗性变化的位点的突变与氯喹抗性间存在关联。 作者从泰国病人分离了64株恶性疟原虫,分别测试了它们对氯喹、甲氟喹等药物的
Plasmodium falciparum resistance is worsening. Studies have shown that the resistance of Plasmodium to chloroquine and mefloquine is related to the Pfmdrl gene and its encoded product p-glycoprotein (pgn1), but there are quite a few different experimental results. This study of P. falciparum isolated from Thailand showed no absolute association between amplification of the Pfmdrl gene and resistance to mefloquine; nucleic acid sequence analysis also failed to demonstrate that some of the genes in this gene may cause drug resistance Mutations in the altered sites are associated with chloroquine resistance. The authors isolated 64 P. falciparums from Thai patients and tested them against chloroquine, mefloquine and other drugs