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目的:探讨胃癌患者外周血中白介素17(IL-17)、白介素6(IL-6)和转化生长因子-β1(TGF-β1)的表达水平及其临床意义。方法:选择2009年1月~2010年1月我院收治的50例胃癌患者(观察组)及同期50例健康对照者(对照组)为研究对象,采用ELISA法检测和比较其外周血中IL-17、IL-6和TGF-β1的水平,并分析胃癌患者外周血中IL-17、IL-6和TGF-β1水平与其临床病理特征之间的相关性。结果:观察组患者外周血中IL-17、IL-6和TGF-β1的水平分别为(8.51±2.68)pg/ml、(7.81±5.41)pg/ml和(1093.42±831.21)pg/ml,均明显高于健康对照组(P<0.01)。胃癌患者的血清IL-17、TGF-β1的水平与其年龄、性别、临床分期、有无淋巴结转移、分化程度、肿瘤部位及大小均无明显相关性(P>0.05);而血清IL-6的水平与肿瘤的大小相关(P<0.05),但与其他临床病理特征无关(P>0.05);血清IL-17水平与IL-6、TGF-β1的水平均无明显相关性(P>0.05)。结论:血清IL-17、IL-6和TGF-β1水平的升高与胃癌的发生有关,但IL-6和TGF-β1可能不是血清中IL-17生成的诱导因子。
Objective: To investigate the expression of interleukin 17 (IL-17), interleukin 6 (IL-6) and transforming growth factor-β1 (TGF-β1) in peripheral blood of gastric cancer patients and its clinical significance. Methods: Fifty gastric cancer patients (observation group) and 50 healthy controls (control group) admitted to our hospital from January 2009 to January 2010 were selected as the research objects. The levels of IL 17, IL-6 and TGF-β1 levels in peripheral blood of patients with gastric cancer, and to analyze the correlation between the levels of IL-17, IL-6 and TGF-β1 in peripheral blood and the clinicopathological features. Results: The levels of IL-17, IL-6 and TGF-β1 in peripheral blood were (8.51 ± 2.68) pg / ml, (7.81 ± 5.41) pg / ml and (1093.42 ± 831.21) pg / Were significantly higher than the healthy control group (P <0.01). Serum levels of IL-17 and TGF-β1 in patients with gastric cancer had no significant correlation with age, gender, clinical stage, lymph node metastasis, differentiation degree, tumor location and size (P> 0.05) (P <0.05), but not with other clinicopathological features (P> 0.05). Serum IL-17 level had no significant correlation with the levels of IL-6 and TGF-β1 (P> 0.05) . CONCLUSIONS: Elevated serum levels of IL-17, IL-6 and TGF-β1 are associated with the development of gastric cancer, but IL-6 and TGF-β1 may not be the inducing factors of IL-17 production in serum.