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美国Medimmune公司的研究者研制了一种有希望的、预防尿路感染的菌苗,此菌苗在研究小鼠中能降低引起感染的大肠杆菌的水平.尿路感染是细菌性和病毒性疾病中最常见的一种.此病常见于妇女,30岁妇女约有半数至少发生过一次感染,许多人反复感染,每年造成800万次就诊,医疗费用超过10亿美元.Medimmune公司与美国华盛顿大学医学院及瑞典Karolinska研究所合作研制了一种采用独特方法阻止大肠杆菌攻击的菌苗.此菌苗是由FimH粘附素分子组成,而粘附素可使细菌粘附于膀胱壁.FimH粘附素是菌毛的一种成分.先前用完整菌毛纤维制备的菌苗效果很差,因为各菌株间菌毛的变异性很大,而粘附素分子则很保守.研究者用菌苗接种小鼠,9周后用大肠杆菌攻击.在29周研究中,接种小鼠膀胱中的细菌数比对照小鼠少99%.在体外实验中同样发现,抗两种粘附素变体的抗体能阻止52个大肠杆菌株中的49株粘附于膀胱细胞.
Researchers at Medimmune in the US have developed a promising vaccine against urinary tract infections that reduce the level of Escherichia coli that causes infections in mice studied, urinary tract infections are bacterial and viral diseases Of the most common one.The disease is common in women, about 30% of women about half of at least one infection, many people repeatedly infected each year, causing 8 million visits, the cost of medical care more than 1 billion US dollars.Medimmune and the University of Washington The Institute of Medicine and the Swedish Karolinska Institute have developed a vaccine that uses a unique approach to stop E. coli bacteria, which is made of FimH adhesin molecules and adhesins that allow bacteria to adhere to the bladder wall. Annexin is a component of the pili.Previous use of intact pili fibers prepared by the vaccine is very poor, because of the variability of the strains between the strains of a large, and very sticky adherent molecules.Researchers with vaccine Mice were vaccinated and challenged with E. coli after 9 weeks In the 29 week study, the number of bacteria in the inoculated mice bladder was 99% less than in the control mice.It was also found in in vitro experiments that the anti-2 adhesin variants Antibodies stop 52 large intestine It strains 49 adhered to the bladder cells.