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目的探讨牙龈环切辅助牙周炎患牙正畸施压前后龈沟液中白介素-1β(IL-1β)、前列腺素E2(PGE-2)水平的变化。方法将208例牙周炎患者随机分为试验组和对照组各104例。所有患者牙周基础治疗2周后给予正畸压入治疗,试验组于排齐整平阶段配合牙龈环切术治疗,对照组于排齐整平阶段不配合牙龈环切术治疗。分别检测2组治疗前后龈沟液中IL-1β和PGE-2水平并比较其差异。结果治疗前2组龈沟液IL-1β、PGE-2水平差异均无统计学意义(P>0.05)。治疗后2组患者龈沟液各分子水平均有所增高,但试验组增高幅度大于对照组,差异均有统计学意义(P<0.05)。结论牙龈环切辅助牙周炎患牙正畸可显著提高患者龈沟液中IL-1β、PGE-2水平,有助于患者康复。
Objective To investigate the changes of interleukin-1β (IL-1β) and prostaglandin E2 (PGE-2) levels in gingival crevicular fluid before and after orthodontic treatment with gingival incision-assisted periodontitis. Methods 208 cases of periodontitis patients were randomly divided into experimental group and control group of 104 cases. All patients underwent orthodontic treatment after 2 weeks of basic periodontal treatment. The experimental group was treated with gingival circumcision in the stage of alignment and flattening, while the control group was not treated with gingival circumcision in the stage of alignment and flattening. The levels of IL-1β and PGE-2 in gingival crevicular fluid of two groups before and after treatment were respectively measured and compared. Results There were no significant differences in the levels of IL-1β and PGE-2 between the two groups before treatment (P> 0.05). After treatment, the levels of gingival crevicular fluid in each group were higher than those in the control group, but the difference was statistically significant (P <0.05). Conclusion Gingival circumcision assisted orthodontic treatment of periodontitis can significantly increase the levels of IL-1β and PGE-2 in gingival crevicular fluid of patients, which is helpful for the recovery of patients.