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白藜芦醇是虎杖的活性成分之一,作为抗氧化剂具有多种复杂的作用机制,是近年来研究的热点课题。细胞色素P450是体内具有多种代谢底物的混合功能氧化酶,其作用底物多数是环境中常见的前致癌物和前毒物,细胞色素P450催化前致癌物和前毒物形成终致癌物,是癌症等多种疾病在机体发生发展的始动因素。乙醇是诱导其活性增加、进而引发酒精性肝病的因素之一,探索细胞色素P450致病机制、寻找抑制细胞色素P450的药物研究对于防治肿瘤和酒精性肝病等多种疾病的发生发展具有重要意义。
Resveratrol is one of the active components of Polygonum cuspidatum. As an antioxidant, it has a variety of complex mechanism of action, which is a hot topic in recent years. Cytochrome P450 is a mixed functional oxidase with many kinds of metabolic substrates in the body. Most of its acting substrates are pro-carcinogens and pro-toxic agents that are common in the environment. Cytochrome P450 catalyzes the formation of final carcinogens by pro-carcinogens and pro-toxins. Cancer and other diseases occur in the body of the initiating factor. Ethanol is one of the factors inducing the increase of its activity and then causing alcoholic liver disease. It is of great significance to explore the pathogenesis of cytochrome P450 and to find a drug that inhibits cytochrome P450 in the prevention and treatment of various diseases such as cancer and alcoholic liver disease .