胎儿在子宫内受到基因毒剂作用而发生的基因损伤,可能导致先天畸形、基因突变和出生后发生肿瘤。诱发姊妹染色单体交换(SCE)和微核形成(MH)是研究胎儿和母亲受到基因毒剂作用而引起遗传学损伤的两种方法。本文报告由环磷酰胺(CP)、丝裂霉素C(MC)和甲苄肼(PC)诱发SCE和由CP诱发MN的试验结果,用以评 Gene damage caused by fetal genotoxicity in the uterus may lead to congenital malformations, gene mutations and tumor development after birth. Induced Sister Chromatid Exchange (SCE) and Micronuclei Formation (MH) are two methods to study the genotoxic effects of fetal and maternal genotoxic agents. This article reports the results of a test of SCE and MN induced by CP induced by cyclophosphamide (CP), mitomycin C (MC) and procarbazine (PC)