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用改进的方法合成了氯丁吗脲,并对其解热、消炎和对单核吞噬细胞功能的影响进行了试验。结果表明氯丁吗脲对大鼠啤酒酵母局部注射的发热的解热作用强度和降温维持时间与乙酰水扬酸相近。对巴豆油引起的小鼠耳炎有明显的抑制作用,较乙酰水扬酸稍强。氯丁吗脲对单核吞噬细胞功能无明显影响。
Neoprene was synthesized by a modified method and its effects on antipyretic, anti-inflammatory and the function of mononuclear phagocytes were tested. The results show that chlorpromazine on the local brewer’s yeast fever and antipyretic strength of the anti-heat retention time and acetylsalic acid similar. Caused by the croton oil mouse otitis have significant inhibitory effect, slightly stronger than acetylsalicylic acid. Neoprene had no significant effect on mononuclear phagocyte function.