别嘌醇致中毒性表皮坏死松解症死亡1例

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患者,男,62岁,因“躯干红斑、丘疹伴瘙痒10多天,泛发全身7 d”入院。患者既往有糖尿病史10多年,服用阿卡波糖1 mg tid,自述血糖控制良好。发现血压升高2月余,最高达200/118 mmH g,服用硝苯地平控释片60 mg qd,血压控制在130~140/70~80 mmH g。肾功能不全2个多月,服用金水宝胶囊3粒tid等保肾治疗。患者20余天前因“高尿酸血症”服用别嘌醇片(重庆青阳药业有限公司,批号: Patient, male, 62 years old, due to “torso erythema, papules with itching over 10 days, generalized 7 d ” admission. The patient had a history of diabetes more than 10 years, taking acarbose 1 mg tid, readme glycemic control. Found that blood pressure increased more than 2 months, up to 200/118 mmH g, taking nifedipine GITS 60 mg qd, blood pressure control in the 130 ~ 140/70 ~ 80 mmH g. Renal insufficiency more than 2 months, taking Jin Shui Bao capsule 3 tid kidney treatment. Patients with more than 20 days ago due to “hyperuricemia ” taking allopurinol tablets (Chongqing Qingyang Pharmaceutical Co., Ltd., batch number:
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