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目的:探讨联合检测血清糖抗原199(CA199),糖抗原242(CA242),甲胎蛋白(AFP),癌胚抗原(CEA)和铁蛋白(Ferr)对原发性肝癌(PLC)的诊断价值。方法:收集2013年1月—2015年12月青海省传染病专科医院肝病科及专家门诊确诊的75例PLC患者,采用罗氏电化学发光技术联合检测患者CA199、CA242、AFP、CEA、Ferr水平。结果:PLC患者五项指标阳性率均高于正常组。PLC患者血清CA199(141.13±127.14)U/mL、CA242(31.62±27.56)U/mL、AFP(322.78±285.60)IU/mL,(5.76±5.44)ng/mL、Ferr(760.22±530.19)mg/mL,明显高于健康对照组CA199(6.44±6.21)U/mL、CA242(5.73±3.67)U/mL、AFP(5.41±4.31)IU/mL、CEA(1.92±1.56)ng/mL、Ferr(132.45±50.46)mg/mL,五项指标差异均有显著性(P<0.01)。结论:五项指标联合检测可提高PLC的诊断率。
Objective: To investigate the diagnostic value of combined detection of serum carbohydrate antigen 199 (CA199), carbohydrate antigen 242 (CA242), AFP, CEA and Ferr in primary hepatocellular carcinoma (PLC) . Methods: Seventy-five PLC patients diagnosed by Department of Hepatology and Specialist Clinic of Infectious Disease Hospital of Qinghai from January 2013 to December 2015 were enrolled in this study. The levels of CA199, CA242, AFP, CEA and Ferr in patients with PLC were detected by Roche electrochemiluminescence. Results: The positive rates of all five indicators in PLC patients were higher than those in normal controls. The serum level of CA199 (141.13 ± 127.14) U / mL, CA242 (31.62 ± 27.56) U / mL, AFP of 322.78 ± 285.60, 5.76 ± 5.44 ng / mL and Ferr of 760.22 ± 530.19 mg / mL was significantly higher than that of CA199 (6.44 ± 6.21) U / mL, CA242 (5.73 ± 3.67) U / mL, AFP (5.41 ± 4.31) IU / mL and CEA (1.92 ± 1.56) ng / 132.45 ± 50.46) mg / mL, all of the five indicators had significant difference (P <0.01). Conclusion: Combined detection of five indicators can improve the diagnostic rate of PLC.