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慢性粒细胞白血病是源于骨髓造血干细胞恶性增殖的克隆性疾病。其CD34抗原阳性伴bcr／ ab(?)融合基因阳性的白血病细胞具有独特的生物学特征,并与病情进展及转归相关。清除CD34阳性慢性粒细胞白血病细胞有助于防止疾病复发。本文就其近年来的研究进展作一综述。
Chronic myeloid leukemia is a clonal disease derived from the malignant proliferation of bone marrow hematopoietic stem cells. The leukemic cells with positive CD34 antigen and bcr / ab (?) Fusion gene have unique biological characteristics and are associated with the progression of disease and prognosis. Clearance of CD34-positive chronic myeloid leukemia cells helps prevent disease recurrence. This article summarizes the research progress in recent years.