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胞嘧啶脱氨酶(Cytosine deaminase,CD/5-氟胞嘧啶(5-FC)系统作为大肠癌尤其是结肠癌肝转移基因治疗应用最为广泛的自杀基因治疗系统,但其治疗的靶向性比较低;我们前期大量的细胞实验已经证明癌胚抗原(CEA)转录调控序列(TRS)可以调控胞嘧啶脱氨酶(CD)基因在CEA阳性的结肠癌组织
Cytosine deaminase (CD / 5-fluorocytosine (5-FC) system is the most widely used suicide gene therapy system for colorectal cancer, especially colon cancer liver metastasis gene therapy, but its therapeutic targeting Low; our previous large number of cell experiments have proved that carcinoembryonic antigen (CEA) transcriptional regulatory sequence (TRS) can regulate cytosine deaminase (CD) gene in CEA positive colon cancer tissue