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目的：探讨广泛性焦虑障碍患者血浆非酶类抗氧化物水平是否存在抗氧化能力降低及氧化应激损伤。方法对35例广泛性焦虑障碍患者（研究组）和35名健康成人（对照组）的外周血非酶类抗氧化物血浆白蛋白、总胆红素、尿酸水平进行检测分析，采用汉密顿焦虑量表评定研究组的焦虑程度。结果研究组血浆白蛋白水平显著低于对照组（t＝8．51，P＜0．01），血浆总胆红素和尿酸水平与对照组比较差异无显著性（P＞0．05）。研究组血浆白蛋白水平与汉密顿焦虑量表总分呈显著正相关（r＝0．38，P＜0．05）。结论广泛性焦虑障碍患者血浆非酶类抗氧化物白蛋白水平明显下降，存在抗氧化能力降低和氧化应激损伤。“,”Objective To explore plasma non‐enzyme antioxidant levels in pa‐tients with generalized anxiety disorder (GAD) and whether there were antioxi‐dant capacity decrease and oxidative stress injury .Methods Plasma non‐enzyme antioxidants levels of al‐bumin ,total bilirubin and uric acid were detected and analyzed in 35 GAD patients (study group) and 35 health adults (control group) ,anxious degrees assessed with the Hamilton Anxiety Scale (HAMA) .Re‐sults The plasma albumin level was significantly lower in study than in control group (t = 8 .51 ,P 0 .05) .Plasma albu‐min level was positively related to the total score of the HAMA in study group notably (r = 0 .37 ,P <0 .05) .Conclusion GAD patients have notably lowered plasma albumin level ,lowered antioxidant capaci‐ty and oxidative stress injury .