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目的了解近20年来广东地区大肠癌临床流行病学特征的变化规律和趋势。方法总结分析广州南方医院和广东惠州市中心人民医院1985—2004年经病理确诊的大肠癌3870例资料。将20年资料按每5年为一时期进行统计分析。结果1985—1989年段与2000—2004年段比较,大肠癌收治率增加102.0%,平均每年上升5.1%;发病中位年龄从50.2岁上升至58.6岁,上升了8.4岁;男女比例逐渐下降,从1.50下降到1.35;发病部位直肠癌比例从64.8%下降到49.7%,右半结肠癌比例则从18.0%上升到28.7%;组织学类型中,中高分化者占的比例从70.1%上升到80.6%,低未分化者比例则从29.9%下降到19.4%;诊断Dukes A期的大肠癌比例从3.2%上升到9.8%。结论近20年来广东地区大肠癌的发病率上升;发病中位年龄上升;男女比例下降;直肠癌比例下降,右半结肠癌上升;组织学类型高中分化者占的比例上升,低未分化者下降;诊断Dukes A期的比例上升。
Objective To understand the changing rules and trends of clinical epidemiological characteristics of colorectal cancer in Guangdong in recent 20 years. Methods The data of 3870 cases of pathologically confirmed colorectal cancer from 1985 to 2004 in Guangzhou Nanfang Hospital and Central Hospital of Huizhou, Guangdong Province were summarized and analyzed. The 20-year data will be statistically analyzed every five years. Results The prevalence of colorectal cancer increased by 102.0% from 1985 to 1989 in the period from 2000 to 2004, with an average annual increase of 5.1%. The median age of onset increased from 50.2 to 58.6 years old, an increase of 8.4 years. The male-female ratio decreased gradually, From 1.50 to 1.35. The incidence of rectal cancer decreased from 64.8% to 49.7%, while that of right colon cancer increased from 18.0% to 28.7%. In histological types, the proportion of moderately to highly differentiated patients increased from 70.1% to 80.6 %, Low undifferentiated decreased from 29.9% to 19.4%; diagnosis of Dukes A colon cancer increased from 3.2% to 9.8%. Conclusions The incidence of colorectal cancer increased in Guangdong in the recent 20 years. The median age of the patients increased. The proportion of men and women decreased. The proportion of rectal cancer decreased and the right colon cancer increased. The proportion of high school students with histological type increased, while that of low undifferentiated patients decreased The proportion of diagnosing Dukes A increased.