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哮喘是一种慢性炎症性气管疾病。长期的炎症可以引起气道结构的改变和重塑,典型的变化如平滑肌肥大、粘液腺增生,血管增殖和基底层增厚。这些变化常导致气道功能改变,如通气阻塞或气道高反应性。咳嗽型哮喘是哮喘的一种形式,表现为单一的慢性咳嗽,作者曾报道过此类哮喘患者肺泡和支气管组织中嗜酸粒细胞增多,其增多程度与疾病严重性的关系。这类哮喘与典型的哮喘一样,与气道炎症有关。但是否发生气道重塑还不知道。 作者对16例各种咳嗽型哮喘的患者(6男,10女,平均年龄48.4±2.6)、22例典型哮喘患者(11男,11女,平均年龄42.0±3.1)和8例健康对照者(3男,5女,平均年龄51.9±1.9)做了支气管组织活检。要求患者持续咳嗽8周以上;无气喘和呼吸困难;对乙酰甲胆碱气道反应性高;用支气管
Asthma is a chronic inflammatory tracheal disease. Long-term inflammation can cause changes and remodeling of the airway structure, typical changes such as smooth muscle hypertrophy, mucus gland hyperplasia, vascular proliferation and basal layer thickening. These changes often lead to changes in airway function, such as obstruction of ventilation or airway hyperresponsiveness. Cough-type asthma is a form of asthma characterized by a single chronic cough. The authors have reported the association of increased eosinophilia in the alveoli and bronchial tissues of these asthmatic patients with increased severity of the disease. This type of asthma, like typical asthma, is associated with airway inflammation. But whether airway remodeling is not known yet. The authors evaluated 16 patients with various cough-type asthma (6 males and 10 females, mean age 48.4 ± 2.6), 22 patients with typical asthma (11 males and 11 females, mean age 42.0 ± 3.1) and 8 healthy controls 3 men and 5 women, mean age 51.9 ± 1.9) had a bronchial biopsy. Patients are required to continue coughing for more than 8 weeks; no asthma and dyspnea; high reactivity to methacholine; bronchial