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本实验用多管微电极细胞外记录和离子微电泳方法，在水含氯醛麻醉的ＳＤ大鼠上观察了γ－氨基丁酸（ＧＡＢＡ）和５－羟色胺（５－ＨＴ）以及它们的受体阻断剂（印防已毒素和赛庚啶）对丘脑束旁核（Ｐｆ）单位痛放电的影响。结果表明：（１）电泳ＧＡＢＡ可抑制Ｐｆ神经元的痛放电，这作用可被电泳印防已毒素所阻断，而单独电泳印防己毒素可加强Ｐｆ的痛放电。（２）电泳５－ＨＴ对Ｐｆ单位痛放电在有些单位表现加强作用，另一些单位表现抑制作用，仅前者可被电泳赛庚啶所阻断。上述结果提示：在Ｐｆ神经元的痛放电活动中，ＧＡＢＡ可能起抑制性作用，而５－ＨＴ可能通过不同的受体亚型既发挥其兴奋作用，也可有抑制作用。
In this study, we used multi-tube microelectrode extracellular recording and ion micro-electrophoresis to observe the effects of γ-aminobutyric acid (GABA) and serotonin (5-HT) and their receptors on SD rats exposed to chloral hydrate Effect of Blockers (Toxin Contained and Cyproheptadine) on Pain Relief in Parafascicular Parafascicular Nucleus (Pf) Units. The results showed that: (1) Electrophoresis of GABA could inhibit the pain discharge of Pf neurons, which could be blocked by electrophoretic inactivation of toxin. (2) Electrophoresis 5-HT on Pf unit pain discharge in some units to enhance performance, while others showed inhibition, only the former can be blocked by electrophoresis cyproheptadine. The above results suggest that GABA may play an inhibitory role in the pain-discharge activity of Pf neurons, while 5-HT may exert both of its excitatory and inhibitory effects through different receptor subtypes.