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[目的]探讨生活干预对肥胖青少年动脉粥样硬化危险因素的影响。[方法]2007年在济南市历下区选择35名肥胖中学生,进行为期8个月的生活干预,于干预前后分别检测血压、颈动脉内膜中层厚度、内皮依赖的血管舒张功能、最大的腹膜前脂肪厚度和最小的皮下脂肪厚度、血清胰岛素、高敏C反应蛋白、甘油三酯、高密度和低密度脂蛋白胆固醇,计算稳态模型胰岛素抵抗指数。[结果]干预后高敏C反应蛋白、胰岛素抵抗指数、空腹胰岛素、最大的腹膜前脂肪厚度、收缩压、甘油三酯、低密度脂蛋白降低(P<0.01或P<0.05)。[结论]适当有效的生活干预,能够改善肥胖青少年的动脉粥样硬化危险因素。
[Objective] To investigate the effect of life intervention on the risk factors of atherosclerosis in obese adolescents. [Methods] Thirty-five obese middle school students were selected in Lixia District of Jinan City in 2007 for 8-month life intervention. Blood pressure, carotid artery intima-media thickness, endothelium-dependent vasodilatation, Steady-state model insulin resistance index was calculated using the thickness of the anterior fat and the thickness of the subcutaneous fat, serum insulin, high-sensitivity C-reactive protein, triglycerides, high density and low density lipoprotein cholesterol. [Results] High-sensitivity C-reactive protein, insulin resistance index, fasting insulin, maximal peritoneal fat thickness, systolic blood pressure, triglyceride and low density lipoprotein were decreased after intervention (P <0.01 or P <0.05). [Conclusion] Appropriate and effective life intervention can improve the risk factors of atherosclerosis in obese adolescents.