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我国现行推广使用的吸附精制白喉类毒素(简称吸精白类),免疫效果良好,一般反应轻微,异常反应罕见,已为国內卫生防疫工作者多年来的使用和重点观察结果所证实。近十年来白喉在年长儿童(尤其学龄儿童)中发病增多的情况,国内外均有报道。如1970年美国某城市白喉流行,发病率以10～14岁组最高,5～9岁组次之(1)。我省情况也是如此,1963年德庆县白喉流行,7岁以下学龄前儿童的发病数为8～15岁学龄儿童的2倍(2)。而1975年紫金、英德、罗定等县白喉流行,8～15岁学龄儿童的发病数为7岁以下的2～4倍(3、4、5)。
Absorption and purification of diphtheria toxoid (abbreviated as astringent white) promoted and used in China now has good immunization effect, slight general reaction and rare abnormal reaction, which has been confirmed by many years’ use and key observation results by domestic health and epidemic prevention workers. Diphtheria in the past decade in older children (especially school-age children) increased incidence of cases, both at home and abroad have been reported. Such as the prevalence of diphtheria in a city in the United States in 1970, the highest incidence of 10 to 14-year-old group, followed by 5 to 9-year-old group (1). The same is true in our province, 1963 Deqing prevalence of diphtheria, preschool children under the age of 7 incidence of 8 to 15-year-old school-age children 2 times (2). In 1975, Zijin County, Yingde County and Luoding County were prevalence of diphtheria. The incidence of school-age children aged 8-15 years was 2 to 4 times that of children under 7 years old (3,4,5).