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目的:探讨维吾尔族和汉族妇女宫颈鳞癌中CRT、ERP57蛋白的表达及其相关性。方法:采用免疫组化SP法检测子宫颈炎组织69例(汉族38例,维吾尔族31例)以及子宫颈磷癌组织124例(汉族36例,维吾尔族88例)中CRT、ERP57蛋白的表达。结果:CRT、ERP57蛋白在宫颈磷癌中的阳性表达率(90.32%、90.32%)均分别高于其在宫颈炎组织中的表达(50.72%、49.28%),差异具有统计学意义(P<0.05)。维吾尔族妇女宫颈磷癌中ERP57的阳性表达率(94.32%)显著高于汉族妇女(80.56%),差异具有统计学意义(P<0.05),两族妇女宫颈磷癌中CRT的阳性表达率比较无统计学差异(P>0.05)。维吾尔族妇女宫颈磷癌中CRT与ERP57阳性表达间呈显著正相关(r=0.229,P<0.05)。结论:CRT、ERP57蛋白上调与维吾尔族和汉族妇女宫颈鳞癌的发生相关,二者在维吾尔族妇女宫颈鳞癌的发生中可能起着更加重要的作用。
Objective: To investigate the expression of CRT and ERP57 protein in Uigur and Han women with cervical squamous cell carcinoma and its correlation. Methods: Immunohistochemical SP method was used to detect the expression of CRT and ERP57 protein in 69 cases of cervicitis (38 Han cases, 31 Uygur cases) and 124 cases of cervical carcinoma (36 Han cases and 88 Uygur cases) . Results: The positive rate of CRT and ERP57 protein in cervical cancer was higher than that in cervicitis (90.32%, 90.32%, 50.72%, 49.28%, P < 0.05). The positive expression rate of ERP57 in cervical cancer of Uyghur women was significantly higher than that of Han women (94.32%) (80.56%), the difference was statistically significant (P <0.05). The positive expression rate of CRT in two groups of cervical cancer No statistical difference (P> 0.05). There was a significant positive correlation between the expression of CRT and ERP57 in Uygur women with cervical cancer (r = 0.229, P <0.05). Conclusion: The upregulation of CRT and ERP57 proteins is related to the occurrence of cervical squamous cell carcinoma in Uygur and Han women, both of which may play a more important role in the occurrence of cervical squamous cell carcinoma in Uighur women.