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目的: 观察现场应用青蒿琥酯预防日本血吸虫感染的效果。方法: 1997 年7 ~9 月, 分别在望江县杨河试区及贵池市沙山试区选择易感人群562 例与218 例, 将受试者随机分为两组, 按双盲法分服青蒿琥酯和安慰剂, 剂量均为6 mg/kg 顿服, 受试者在接触疫水后2 wk 开始服药, 每2 wk 1 次, 连服4 次, 接受全程试验者末次服药后4 wk , 用尼龙绢集卵法加改良加藤法进行效果评价。结果: 杨河试区服药组273 例中2 例孵化阳性,阳性率为07 % ; 对照组289 例粪检阳性11 例, 阳性率为38 % , E P G 为2640 ±149 个。沙山试区服药组107例粪检均为阴性, 对照组111 例粪检阳性7 例, 感染率为63 % , E P G 为1423 ±214 个。两试区青蒿琥酯预防血吸虫感染的保护率分别为809 % 与100 % 。结论: 口服青蒿琥酯能有效地预防日本血吸虫感染。
Objective: To observe the effect of artesunate in preventing Schistosoma japonicum infection in the field. Methods: From July to September 1997, 562 and 218 cases of susceptible population were selected in Yanghe Trial District of Wangjiang County and Shashan District of Guichi City respectively. Subjects were randomly divided into two groups according to double-blind method The dose of artesunate and placebo was 6 mg / kg daily. The subjects started taking medication 2 wk after the exposure to water and once every 2 weeks for 4 consecutive times, and received the last dose After 4 wk, with nylon silk egg method plus improved Kato method for evaluation. Results: 2 of 273 cases in Yanghe test group were hatched positive, the positive rate was 07%. In the control group, 289 cases were stool positive, the positive rate was 38%, and the E P G was 2640 ± 149. In the test group of Shashan District, 107 cases were negative for stool test, while 111 cases for the control group were stool positive. The infection rate was 63% and the E P G was 1423 ± 214. The protection rates of artesunate against schistosomiasis in two experimental areas were 80.9% and 100% respectively. Conclusion: Oral administration of artesunate can effectively prevent Schistosoma japonicum infection.