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目的探讨ＳＬＥ医院感染危险因素，为控制院内感染提供依据。方法对１０８例ＳＬＥ发生医院感染的众多危险因素进行分析和医院内感染分析和医院内感染发病率调查。结果１０８例ＳＬＥ住院１２０例次，有８４例次发生医院内感染，院内感染发生率７０％（８４／１２０）。感染的危险因素有抗生素应用、激素、免疫抑制剂应用、住院时间大于３周等７个因素有统计学意义。用非条件Ｌｏｇｉｓｔｉｃ回归分析表明，对自身因素中狼疮肾炎、狼疮脑、狼疮肺，医源性因素中应用抗菌药物、激素与免疫抑制剂以及住院时间３周以上的患者，应高度警惕医院感染发生的可能。结论医院感染是ＳＬＥ患者死亡的主要原因及加速病情恶化的因素，加强防治工作，是延长存活期，降低病死率的重要环节
Objective To investigate the risk factors of SLE hospital infection and provide the basis for the control of nosocomial infection. Methods The risk factors of nosocomial infection in 108 cases of SLE were analyzed and the incidence of nosocomial infection was analyzed. Results A total of 108 SLE patients were hospitalized in 120 cases, with 84 cases of nosocomial infections and 70% (84/120) cases of nosocomial infections. Risk factors for infection are antibiotics, hormones, immunosuppressive agents, hospitalization time is greater than 3 weeks and other seven factors were statistically significant. Non-conditional Logistic regression analysis showed that patients with lupus nephritis, lupus brain, lupus lung, iatrogenic factors such as antibiotics, hormones and immunosuppressive agents and hospital stay longer than 3 weeks should be highly vigilant against nosocomial infections Possible. Conclusion Nosocomial infection is the main cause of death in patients with SLE and the factors that exacerbate the exacerbation of diseases. Strengthening prevention and treatment is an important link in prolonging survival and reducing mortality