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目的设计合成一系列3,4-二氢-4-芳基香豆素类化合物,并评价其抗氧化、抗肿瘤活性。方法以取代苯甲醛为原料,经缩合及Ponndorf反应制得目标化合物。采用DPPH法测定目标化合物的抗氧化活性;采用MTT法以胃癌细胞BGC-823为测试细胞株对目标化合物进行体外抗肿瘤活性评价。结果与结论合成了10个新的3,4-二氢-4-芳基香豆素类化合物,目标化合物的结构经质谱、红外、核磁共振氢谱确证。部分化合物(3c、3d、3f、3g)具有很强的抗氧化活性,化合物3a、3c、3g、3i、3j对人胃癌细胞BGC-823具有较弱的抑制作用。
Aim To design and synthesize a series of 3,4-dihydro-4-arylcoumarins and evaluate their anti-oxidation and anti-tumor activities. Methods Substituted benzaldehyde was used as the starting material to obtain the target compound by condensation and Ponndorf reaction. The anti-oxidative activity of the target compound was determined by DPPH method. The anti-tumor activity of the target compound in vitro was evaluated by MTT method using the gastric cancer cell line BGC-823 as the test cell line. RESULTS AND CONCLUSION Ten new 3,4-dihydro-4-arylcoumarins were synthesized. The structures of target compounds were confirmed by MS, IR and 1H-NMR. Some compounds (3c, 3d, 3f, 3g) have strong antioxidant activity. Compounds 3a, 3c, 3g, 3i, 3j have weaker inhibitory effect on human gastric cancer cells BGC-823.