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目的:优选银花痤疮酊的组方及制备工艺。方法:以体外抑菌试验及制剂稳定性加权评分作为考察指标,主要考察以下方面:①组方是否合理,能否减少药味;②乙醇渗漉后的药渣是否有必要再用水煎煮提取;③可否加入甘油作为防腐剂;④能否用活性炭脱色。结果:①组方在原方基础上去掉夏枯草等6味药后无显著性差异;②药渣不需要煎煮;③可加入甘油;④不能用活性炭脱色。结论:该制剂有良好的体外抑菌作用并且质量可控。
Objective: To optimize the prescription of Yinhua acne tincture and its preparation process. Methods: In vitro antibacterial test and preparation stability weighted score as an index, mainly to investigate the following aspects: ① the prescription is reasonable, can reduce the flavor; ② ethanol percolation residue is necessary and then decocted with water; ③ whether glycerin can be added as a preservative; ④ decolorization with activated carbon. Results: ①There was no significant difference between the two groups after removing six kinds of herbs, such as Prunella vulgaris, on the basis of the original prescription; ② No need to decoction of dregs; ③ Glycerol could be added; ④Colorless can not be decolorized with activated carbon. Conclusion: The preparation has good antibacterial activity in vitro and its quality is controllable.