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糖尿病肾病是糖尿病最常见的微血管并发症之一。PKC的异常激活尤其是PKC-β在糖尿病肾病中的作用已逐渐予以确立,但还得进一步明确除PKC-β之外其他的PKC同工酶在糖尿病肾病发生发展中的作用,阻断DAG/PKC信号通路有望成为治疗糖尿病肾病的一种新方法。
Diabetic nephropathy is one of the most common microvascular complications of diabetes. The abnormal activation of PKC, especially the role of PKC-β in diabetic nephropathy, has been gradually established, but we must further clarify the PKC-β in addition to other PKC isoenzymes in the development of diabetic nephropathy, the role of blocking DAG / PKC signaling pathway is expected to become a new method of treatment of diabetic nephropathy.