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目的观察早期康复治疗对急性脑梗死(ACI)患者的运动功能及日常生活能力、血清超敏C-反应蛋白(hs-CRP)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平的影响。方法将80例ACI患者随机分为两组,康复组40例采用早期康复治疗和常规中西药物治疗,对照组40例仅采用常规中西药物治疗;测定两组患者治疗前和治疗后2和4周后外周血hs-CRP、IL-1 IL-6和TNF-α水平,运动功能采用Fugl-Meyer运动功能积分法(FMA)评定,日常生活能力采用改良Barthel指数评分(MBI)。结果康复组治疗后2和4周时外周血hs-CRP、IL-1和IL-6水平低于对照组(P<0.05);康复组FMA、MBI上升幅度明显高于对照组(P<0.05)。结论早期康复干预可降低急性脑梗死患者患者血清hs-CRP、IL-1、IL-6和TNF-α水平,并能明显改善肢体运动功能,提高日常生活能力。
Objective To observe the effects of early rehabilitation on motor function and daily living ability, serum hs-CRP, IL-1, (IL-6) and tumor necrosis factor-α (TNF-α) levels. Methods Eighty patients with ACI were randomly divided into two groups. Forty patients in rehabilitation group were treated with early rehabilitation and conventional Chinese and Western medicines. Forty patients in control group were treated with routine Chinese and Western medicines only. Before treatment and two and four weeks after treatment The levels of hs-CRP, IL-1, IL-6 and TNF-α in the peripheral blood were measured. The motor function was evaluated by Fg and the improved Barthel index score (MBI). Results The levels of hs-CRP, IL-1 and IL-6 in the peripheral blood of the rehabilitation group were lower than those of the control group at 2 and 4 weeks after treatment (P <0.05), and the increases of FMA and MBI in the rehabilitation group were significantly higher than those of the control group ). Conclusion Early rehabilitation intervention can reduce the serum levels of hs-CRP, IL-1, IL-6 and TNF-α in patients with acute cerebral infarction and can significantly improve limb motor function and improve daily living ability.