目的:研究儿童肺炎支原体肺炎(MPP)外周血中Th1/Th2细胞因子变化及临床意义。方法:回顾性分析2016年1月至2020年2月在杭州市儿童医院接受治疗的MPP患儿60例的临床病例资料，根据病情进展程度将MPP患儿分为急性期组(n n＝29)和恢复期组(n n＝31)，另选取同期于该院进行体检的健康儿童50例作为健康对照组，采用双夹心抗体酶联免疫吸附法(ELISA)检测白细胞介素4(IL-4)、γ-干扰素(IFN-γ)水平。n 结果:MPP急性期组IFN-γ、IL-4水平[(1 235.24±254.64)ng/L、(781.13±113.09)ng/L]均明显高于恢复期组[(545.38±58.57)ng/L、(331.27±64.18)ng/L](n t＝14.683、19.108，均n P＝0.001)和对照组[(477.96±46.61)ng/L、(241.86±39.07)ng/L](n t＝20.534、30.813，均n P＝0.001)，Th1/Th2水平[(1.65±0.37)]明显低于恢复期组[(1.97±0.42)](n t＝3.123，n P＝0.003)和对照组[(2.28±0.56)](n t＝5.405，n P＝0.001)；MPP恢复期组IFN-γ、IL-4水平均高于对照组(n t＝5.729、7.805，n P＝0.003、0.001)，Th1/Th2水平低于对照组(n t＝2.652，n P＝0.010)。n 结论:MPP患儿存在Th2占优势的免疫失调。“,”Objective:To study the changes and clinical significance of Th1/Th2 cytokines in peripheral blood of children with mycoplasma pneumoniae pneumonia(MPP).Methods:The clinical data of 60 MPP children who were treated in the hospital from January 2016 to February 2020 were retrospectively analyzed.According to disease progression, MPP children were divided into acute period group(n n=29) and recovery period group(n n=31). Another 50 healthy children who underwent physical examination in the hospital during the same period were enrolled as healthy control group.The levels of interleukin 4(IL-4) and γ-interferon(IFN-γ) were detected by double sandwich antibody ELISA.n Results:The levels of IFN-γ and IL-4 in the acute period group[(1 235.24±254.64)ng/L, (781.13±113.09)ng/L] were significantly higher than those in the recovery period group[(545.38±58.57)ng/L, (331.27±64.18)ng/L](n t=14.683, 19.108, n P<0.001, <0.001) and the control group[(477.96±46.61)ng/L, (241.86±39.07)ng/L](n t=20.534, 30.813, n P<0.001, <0.001), while Th1/Th2 level(1.65±0.37) in the acute period group was significantly lower than that in the recovery period group(1.97±0.42)(n t=3.123, n P=0.003) and the control group(2.28±0.56)(n t=5.405, n P<0.001). The levels of IFN-γ and IL-4 in the recovery period group were higher than those in the control group(n t=5.729, 7.805, n P=0.003, <0.001), while Th1/Th2 level in the recovery period group was lower than that in the control group( n t=2.652, n P=0.010).n Conclusion:There are immune disorders of Th2 advantages in MPP children.