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目的：评价内镜下粘膜剥离术（ESD）治疗上消化道异位胰腺的临床效果与安全性。方法随机选取宜兴市人民医院2014年8月至2016年1月收治的上消化道异位胰腺住院患者53例，实施ESD手术，并对其内镜表现、病变特征、手术情况、并发症发生情况及随访结果进行记录分析。结果行ESD治疗的患者手术时间平均为67．5 min，切除的病变标本平均大小为21．5 mm×16．0 mm，1例患者术中出现穿孔，1例出现少量出血。患者术后住院平均时间为（4．4±1．2）d，术后1例患者发生上消化道迟发出血，1例患者发生穿孔。53例患者均在2个月内创伤愈合，未见病变残留，12个月内未见异位胰腺复发。结论 ESD治疗上消化道异位胰腺能有效切除病变组织，治疗创伤较小，并发症少，术后恢复快，值得临床推广使用。“,”Objective To evaluate the clinical efficacy and safety of endoscopic submucosal dissection (ESD) treatment for upper gastrointestinal ectopic pancreas. Methods 53 patients with upper gastrointestinal ectopic pancreas hospitalized in our hospital from August 2014 to January 2016 were randomly selected for the study, and they were treated with ESD. The endoscopic and lesion characteristics, operation time and lesion size, removed and wound healing condition and long-term complications of the patients were recorded and analyzed. Results Endoscopic ultrasonography showed that the average size of 53 patients′lesions was 16.5 mm × 8.6 mm, and lesions of 40 cases (75.47%) were from submucosa. The mean operation time of ESD treatment was 67.5 min, and the average size of lesion specimens removed was 21.5 mm×16.0 mm. The mean postoperative hospital stay time was (4.4±1.2) days. During the operation, 1 patient perforated, and another 1 case experienced a small amount of bleeding. Late delayed bleeding in upper gastrointestinal occurred in one patient after operation , and 1 patient perforated after operation. 53 patients of would healed within 2 months, There was no residual lesion and ectopic pancreas did not relapsed with 12 months. Conclusion The treatment of ESD for upper gastrointestinal ectopic pancreas is able to remove lesion tissue effectively with less injury and fewer complications, and helps the patients recover faster, which is worthy of clinical use.