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本次报告采用每月静注一次环磷酰胺的方法治疗复发一缓解型多发性硬化获良好效果.本组共14例患者,均为复发一缓解型多发性硬化,8例用安慰剂,即用5%葡萄糖水溶液250ml静注,6例给予环磷酰胺750mg/m~2静注,每月一次,每次在24小时内每例患者给予液体总量3000ml(5%葡萄糖水溶液和1/4生理盐水).同时给予乙二磺酸甲哌氯丙嗪(prochlorperazine edisylate)或非那根肌注,每6小时一次.上述治疗在12个月的过程中共治疗12次.每月对病人作一次临床评价.结果发现用安慰剂的8例患者中男性2例,女性6例,年龄平均33岁,病程平均5年,用环磷酰胺的6例
The report of a monthly intravenous injection of cyclophosphamide treatment of relapsing and remitting multiple sclerosis achieved good results in this group of 14 patients were relapsing and remitting multiple sclerosis, 8 patients with placebo, that is, The mice were intravenously infused with 250 ml of 5% dextrose in water and intravenous injection of cyclophosphamide (750 mg / m ~ 2) was given to six patients once a month for a total of 3000 ml (5% glucose and 1/4 Saline) given concurrently with prochlorperazine edisylate or pinafine intramuscular injection every 6 hours.The above treatment was treated 12 times in total over a 12-month period, once a month for the patient Clinical evaluation.Results found that 8 patients with placebo in 2 males and 6 females, mean age 33 years, average duration of 5 years, with cyclophosphamide in 6 cases