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对382例头颈部原发鳞癌病人颈清扫标本连续切片病理观察结果和临床资料进行回顾性分析,探讨淋巴结转移的各项临床和病理学因素与病人预后的关系。发现总体5年生存率为46.1%,口腔癌、口咽癌、下咽癌和喉癌的5年生存率分别为49.7%,39.7%,35.0%和60.3%。表明颈淋巴结的临床分期、触诊淋巴结大小、病理转移淋巴结情况、颈淋巴解剖分区受累数和最低受累平面与病人5年生存率有密切关系(均P<0.01),而阳性淋巴的个数对病人预后无明显影响。提示针对影响预后的淋巴结因素应采取相应的治疗措施,以提高病人的5年生存率。
The pathological observations and clinical data of serial sections of neck dissection specimens of 382 patients with primary squamous cell carcinoma of the head and neck were retrospectively analyzed to investigate the relationship between clinical and pathological factors of lymph node metastasis and patient prognosis. The overall 5-year survival rate was 46.1%. The 5-year survival rates for oral cancer, oropharyngeal cancer, hypopharyngeal cancer, and laryngeal cancer were 49.7%, 39.7%, 35.0%, and 60.3%, respectively. The clinical stage, palpated lymph node size, pathological lymph node metastasis, number of cervical anatomical dissections, and the lowest affected plane were closely related to the 5-year survival rate (all P<0.01), and positive lymph nodes were found. The number of patients has no significant effect on the prognosis. It is suggested that appropriate therapeutic measures should be taken for lymph node factors that influence prognosis, so as to improve the 5-year survival rate of patients.