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目的探讨妊娠期高血压疾病患者血清硫化氢(H_2S)水平及其与靶器官损害的相关关系。方法收集86例妊娠期高血压疾病患者,同时选取43例正常妊娠者为对照组,检测两组患者血清中H_2S的水平,再依据靶器官损害的程度将实验组患者分为4组,分析血清中H_2S水平与靶器官损害的关系。结果妊娠高血压患者血清中H_2S水平明显低于正常妊娠者。妊娠期高血压疾病患者中重度子痫前期组患者血清中H_2S水平最低,而妊娠期高血压组患者血清中H_2S水平最高。且靶器官损害的越多妊娠高血压患者血清中H_2S水平越低。结论妊娠期高血压疾病患者血清中H_2S的水平明显低于正常血压的孕妇。妊娠期高血压疾病患者血清中H_2S的水平随着靶器官损害数目的增加而逐渐降低。
Objective To investigate the serum level of hydrogen sulfide (H 2 S) in patients with hypertensive disorder complicating pregnancy and its relationship with target organ damage. Methods 86 cases of hypertensive disorder complicating pregnancy were collected and 43 normal pregnant women were selected as the control group. The levels of H 2 S in serum of the two groups were detected. According to the degree of target organ damage, the experimental group was divided into 4 groups. Serum Relationship between H 2 S level and target organ damage. Results The serum levels of H 2 S in patients with pregnancy-induced hypertension were significantly lower than those in normal pregnancy. The level of H 2 S in the serum of patients with severe preeclampsia was the lowest in patients with gestational hypertension, while the level of H 2 S was the highest in patients with gestational hypertension. And the more target organ damage in patients with pregnancy-induced hypertension serum H 2 S level is lower. Conclusions H 2 S levels in serum of patients with gestational hypertension are significantly lower than those of normal blood pressure. The level of H 2 S in the serum of patients with gestational hypertension gradually decreases with the increase of the number of target organs.