药物的疗效与血药浓度有密切关系,而血药浓度是由吸收、分布、代谢、排泄功能决定的;新生儿、未成熟儿从解剖、生理、药代动力学看与年长儿和成人不同,同时新生儿生后各脏器的功能迅速发育伴药代动力学的急骤变化,因此安全用药,除严格掌握用药指征外,必须了解新生儿药代动力学、给药途径和剂量等,以免影响疗效,乃至造成药物中毒。 Drug efficacy and blood concentration are closely related to the plasma concentration is absorbed, distribution, metabolism, excretion function of the decision; neonatal, immature children from anatomy, physiology, pharmacokinetics and older children and adults Different, while the rapid development of neonatal organ function rapid changes with pharmacokinetic changes, so safe medication, in addition to strict indications for medication, we must understand the neonatal pharmacokinetics, route of administration and dose , So as not to affect the curative effect, and even cause drug poisoning.