抗原提呈细胞调控T细胞免疫是通过B7家族中的一类共激活分子完成的,B7-H4是B7家族中一个新成员。人B7-H4基因位于1号染色体,由六个外显子和五个内含子组成,其中的第六个外显子可用于选择性剪接,最终得到两个不同的产物。B7-H4是T细胞免疫的强弱化子,抑制T细胞增殖和细胞因子分泌。近来研究发现B7-H4蛋白在多种肿瘤组织中大量表达,使肿瘤细胞逃避机体免疫系统的攻击。以B7-H4分子为肿瘤治疗靶标,为肿瘤免疫治疗提供了一种新方法。 Antigen-presenting cells regulate T-cell immunity through a class of co-activation molecules in the B7 family, a new member of the B7 family. The human B7-H4 gene is located on chromosome 1 and consists of six exons and five introns, the sixth of which is available for alternative splicing resulting in two different products. B7-H4 is a weakening and repressor of T cell immunity that inhibits T cell proliferation and cytokine secretion. Recent studies have found that B7-H4 protein is expressed in a large number of tumor tissues to make tumor cells evade the body’s immune system. Taking B7-H4 as a tumor therapeutic target, it provides a new method for tumor immunotherapy.