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寄生虫严重影响人类和牲畜健康,因此亟需有效药物控制和治疗寄生虫疾病。其中以微管蛋白为靶标的抗寄生虫药物已受到广大科研工作者的关注。本文对近年寄生虫微管蛋白特征及其与药物作用机制、抗药性和实验方法相关的研究作一综述,旨在为探索抗寄生虫新型药物提供理论参考。
Parasites seriously affect the health of humans and livestock and there is an urgent need for effective drug control and treatment of parasitic diseases. Among them, anti-parasitic drugs targeting tubulin have attracted the attention of researchers. In this paper, the characteristics of the parasite tubulin and its related mechanism, drug resistance and experimental methods are reviewed in this paper, which aims to provide theoretical reference for the exploration of new antiparasitic drugs.