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目的：研究β2激动药班布特罗的支气管扩张作用。方法：通过测定致敏豚鼠抗原攻击前后的肺阻力（RL）和肺动态顺应性（Cdyn）变化，观察班布特罗对气道的扩张作用。结果：对照组的致敏豚鼠在抗原攻击后1min即达到反应高峰，RL比攻击前增高205．5％，在攻击后1～15min内（每3min测一次）比攻击前平均增高169．5±44．0％；Cdyn下降52．6％，平均下降50．0±4．2％。班布特罗2．0、5．0和10．0mg／kg组在攻击后1min时，RL值比攻击前分别增高80．6％、27．9％和15．0％，攻击后1～15min内（每3min测一次）比攻击前分别平均增高150．3±64．6％、47．7±18．9％和36．9±19．3％；Cdyn在攻击后1min时分别下降35．5％、16．3％和－1．3％，分别平均下降45．5±7．7％、18．6±4．6％和11．8±11．1％。经统计处理，班布特罗5．0和10．0mg／kg组与对照组比较，差异有显著性（分别为P＜0．05，P＜0．01）。结论：班布特罗（灌胃给药）对豚鼠有较强的气道扩张作用。
OBJECTIVE: To investigate the bronchodilator effect of beta-2 agonist bambuterol. Methods: The effects of bambuterol on the airway expansion were observed by measuring the change of pulmonary resistance (RL) and pulmonary dynamic compliance (Cdyn) before and after sensitized guinea pig antigen challenge. Results: The sensitized guinea pigs in the control group reached the peak at 1 min after antigen challenge. The RL increased 205.5% before the challenge and within 1-15 minutes after the challenge (measured every 3 minutes), an increase of 169.5 ± 44.0%; Cdyn decreased by 52.6%, with an average decrease of 50.0 ± 4.2%. The values of RL were increased by 80.6%, 27.9% and 15.0%, respectively, at 1, 2 min post-challenge in the bambuterol 2.0, 5.0 and 10.0 mg / kg groups, Within 15 min (measured every 3 min), the average increase was 150.3 ± 64.6%, 47.7 ± 18.9% and 36.9 ± 19.3% respectively before the challenge; Cdyn decreased by 35 .5%, 16.3% and -1.3% respectively, with an average reduction of 45.5 ± 7.7%, 18.6 ± 4.6% and 11.8 ± 11.1% respectively. After statistical analysis, there was significant difference between the bambuterol 5.0 and 10.0 mg / kg groups and the control group (P <0.05, P <0.01, respectively). Conclusion: Bambuterol (intragastric administration) has a strong airway dilation effect on guinea pigs.