吡啶或吲哚二羧酸甲酯和伯胺或仲胺在四氢呋喃中以Mg Cl2 或 Mg Br2 催化 ,室温进行选择性酰胺化 ,可得相应的酯 -酰胺。 15例收率 90 %～ 99%。吡啶羧酸甲酯或苯乙酸甲酯同法得相应的酰胺。 10例收率 6 6 %～ 99%。温和选择性酰胺化的新方法@胡猛 The pyridine or indole dicarboxylic acid methyl ester and the primary or secondary amine are catalyzed by MgCl 2 or MgBr 2 in tetrahydrofuran at room temperature for selective amidation to give the corresponding ester-amide. 15 cases of the yield of 90% to 99%. Methyl picolinate or methyl phenylacetate corresponds to the corresponding amide. 10 cases of yield 6 6% to 99%. A New Method for Mild Selective Amidation Hu Meng