一个世纪以来,人们已认识到单核吞噬细胞在结核病发病中的重要作用。但是,介导宿主细胞与病原菌结核分枝杆菌相互作用的分子机理尚不完全清楚。适应宿主的结核杆菌形成了多种方式进入单核细胞,并在细胞中存活和生长繁殖。 近年结核病在美国及全球范围内的发病率逐渐上升,促使更多科学家研究胞内病原结核分枝杆菌与免疫系统之间的相互作用。人类宿主初次感染过程中,结核杆菌遇到的第一个专性吞噬细胞是肺泡巨噬细胞。结核杆菌能侵入肺泡巨噬细胞,且能在 For more than a century, it has been recognized that mononuclear phagocytes play an important role in the pathogenesis of tuberculosis. However, the molecular mechanism that mediates the interaction of host cells with pathogenic M. tuberculosis is not fully understood. Host-adapted Mycobacterium tuberculosis forms a variety of ways to enter monocytes and survive and grow in the cells. In recent years, the incidence of tuberculosis in the United States and around the world has been on the rise, prompting more scientists to study the interaction between the intracellular pathogenic Mycobacterium tuberculosis and the immune system. Mycobacterium tuberculosis encountered the first obligate phagocytic cells to be alveolar macrophages during the primary infection of human hosts. Mycobacterium tuberculosis can invade alveolar macrophages, and can be