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目的:观察米非司酮配伍米索前列醇终止生化妊娠的临床效果。方法:采用前瞻性随机对照临床研究,对月经周期规则、停经≤40天的早孕期妇女238例,根据血β-hCG及阴道B超检查结果分为生化妊娠组78例和早期临床妊娠组160例。米非司酮150 mg分次口服,48 h后顿服米索前列醇600μg,之后留院观察6 h,定期随诊观察治疗结局。结果:早期临床妊娠组146例见孕囊排出(91.3%),而生化妊娠组仅8例见孕囊排出(10.3%),大部分妇女仅表现为阴道流血。生化妊娠组阴道出血持续时间为(6.2±0.2)天,早期临床妊娠组阴道出血持续时间为(8.8±0.5)天。生化妊娠组与早期临床妊娠组的完全流产率为97.4%及86.3%,两组比较差异无统计学意义(P>0.05)。生化妊娠组妇女月经如期复潮97.4%,而对照组13.8%未能如期复潮。结论:生化妊娠阶段药物流产是可行的及安全的,完全流产率高,阴道流血时间短,流血量少,月经恢复快。
Objective: To observe the clinical effect of mifepristone and misoprostol in terminating biochemical pregnancy. Methods: A prospective, randomized and controlled clinical study of 238 women with early menstruation who had menstrual cycle ≤40 days and were divided into biochemical pregnancy group (78 cases) and early clinical pregnancy group (160 cases) by blood β-hCG and vaginal B- example. Mifepristone 150 mg sub-orally, 48 h after taking misoprostol 600 ug, then stay in hospital for 6 h, followed up regularly to observe the treatment outcome. Results: In the early clinical pregnancy group, 146 cases were discharged by gestational sac (91.3%), while in the biochemical pregnancy group, only 8 cases were discharged by the gestational sac (10.3%). Most women only showed vaginal bleeding. The duration of vaginal bleeding in the biochemical pregnancy group was (6.2 ± 0.2) days, and the duration of vaginal bleeding in the early clinical pregnancy group was (8.8 ± 0.5) days. The rate of complete abortion in biochemical pregnancy group and early clinical pregnancy group was 97.4% and 86.3%, respectively. There was no significant difference between the two groups (P> 0.05). Women in the biochemical pregnancy group had a 97.4% increase in menstrual cycle as expected, while 13.8% of the control group failed to resume resuscitation. Conclusion: The abortion is feasible and safe during the biochemical gestational period. The rate of complete abortion is high, the vaginal bleeding time is short, the amount of bleeding is less and the menstruation resumes fast.