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目的 糖基化终极产物 (AGEs)是体内蛋白质与糖在无酶条件下发生反应后的产物。正常人体内AGE水平随年龄增长而缓慢增加 ,疾病状态下 ,如糖尿病时循环和组织中AGE修饰蛋白水平明显增加。AGEs主要通过与其受体RAGE相互作用介导一系列病理反应 ,研究表明AGEs可以通过损伤内皮功能、促进平滑肌细胞增殖、诱导心肌细胞凋亡、促进胶原蛋白交联、促进炎症因子及生长因子表达、干扰脂质代谢、影响凝血状态等机制对心血管系统产生损伤 ,阻滞AGEs/RAGE是心血管疾病治疗的新的靶点。
Purpose Glycation end products (AGEs) are the products of proteins and sugars that react in the absence of enzyme. AGE levels in normal subjects slowly increase with age, and AGE-modified proteins are significantly increased in disease states, such as diabetes and tissues. AGEs mainly mediate a series of pathological reactions by interacting with its receptor RAGE. Studies have shown that AGEs can promote the proliferation of smooth muscle cells, induce apoptosis of cardiomyocytes, promote collagen cross-linking and promote the expression of inflammatory factors and growth factors by impairing endothelial function, Interference with lipid metabolism, coagulation status and other mechanisms of cardiovascular system damage, block AGEs / RAGE is a new therapeutic target for cardiovascular disease.