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目的探讨放疗联合顺铂+氟尿嘧啶方案同步化疗治疗晚期局部食管癌患者的临床效果。方法选取2013年1月至2014年1月营口经济技术开发区中心医院收治的110例晚期局部食管癌患者作为研究对象,按照随机数字表法将其分为试验组(放疗联合顺铂+氯尿嘧啶方案同步化疗)与对照组(单纯放疗)。随访2年,比较两组患者治疗效果、1年生存率、2年生存率及不良反应发生情况。结果试验组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);试验组患者的1年生存率、2年生存率均明显高于对照组,差异均有统计学意义(均P<0.05)。结论采用放疗联合顺铂+氯尿嘧啶方案同步化疗治疗晚期局部食管癌临床疗效显著,可有效提升患者生存率,且不良反应较少,安全可靠。
Objective To investigate the clinical effect of concurrent chemotherapy with radiotherapy combined with cisplatin + fluorouracil in the treatment of patients with advanced local esophageal cancer. Methods One hundred and ten patients with advanced esophageal cancer who were treated in Central Hospital of Yingkou Economic and Technological Development Zone from January 2013 to January 2014 were selected as study subjects and divided into experimental group (radiotherapy plus cisplatin + Pyrimidine regimen synchronous chemotherapy) and control group (radiotherapy alone). The patients were followed up for 2 years. The therapeutic effect, 1-year survival rate, 2-year survival rate and adverse reactions of the two groups were compared. Results The total effective rate of treatment group was significantly higher than that of the control group (P <0.05). The 1-year survival rate and 2-year survival rate of the experimental group were significantly higher than those of the control group Significance (both P <0.05). Conclusions The concurrent chemotherapy with radiotherapy combined with cisplatin + chloro-uracil chemotherapy in the treatment of advanced local esophageal cancer has significant clinical effect, which can effectively improve the survival rate of patients with less adverse reactions and is safe and reliable.